Genetic Methylation Test

Blood Test Types

629
Tests Included
  • Genetic Methylation Test
  • MTHFR (Methylenetetrahydrofolate Reductase)
Lab Test Category
  • Baseline
  • Genetic Testing
  • Liver Health
  • Lyme Disease
  • Mold Toxicity
  • Biotoxin Illness & CIRS
Note
  • the test is sent to the lab for results and the results will be provided through email.
  • This test can be purchased without a physician and is an at home Saliva test kit which is shipped to the patient with instructions. Upon completion
Not Available in New York

Genetic Methylation Test

DNA Methylation: The Body's Genetic Control System

DNA methylation influences how various genes function which can impact various aspects of health. A genetic methylation test can help provide insight into the body's methylation pathways and how it may contribute to potential health issues

What is DNA Methylation?

DNA methylation is one of the factors that influences gene expression on how genes are expressed or silenced. The methylation process occurs billions of times each second and serves as molecular control switches which regulate important functions in the body [1]. When these molecular switches work less than optimal, it can result in various health issues, including developmental disorders and diseases [2].

Understanding the Methylation Cycle

The methylation cycle is a biochemical process that occurs throughout every cell in the body, which is closely associated with methylation defects.

  • Powers essential cellular functions
  • Supports detoxification processes
  • Maintains DNA repair mechanisms
  • Regulates neurotransmitter production through the influence of methylation status. [3]

Research has shown that irregularities in methylation can affect health in ways including:

- Cognitive function and mental health - Cardiovascular wellness [4] - Detoxification capabilities [5] - Energy levels and metabolism [6] - Immune system function [7]

The following genes are analyzed in the Genetic Methylation Test:

1. MTHFR (Methylenetetrahydrofolate Reductase)

The MTHFR gene is known for converting folate into its active form usable by the body, and its defects, such as the MTHFR mutation, can impact methylation status. Mutations in this gene can affect:

  • Neurotransmitter production
  • Cardiovascular health
  • Pregnancy outcomes
  • Mental health [8]

2. COMT (Catechol-O-Methyltransferase)

The COMT gene helps regulate neurotransmitter levels and stress response, influencing:

  • Mood stability
  • Cognitive performance
  • Stress resilience
  • Pain sensitivity [9]

3. VDR (Vitamin D Receptor)

The VDR gene determines how effectively the body utilizes vitamin D, which can affect:

  • Bone density
  • Immune function
  • Cancer prevention
  • Mood regulation [10] [11]

4. CBS (Cystathionine Beta-Synthase)

Research the CBS gene plays a role in:

  • Detoxification processes
  • Glutathione production
  • Sulfur metabolism
  • Energy production [12]

5. MTR/MTRR Complex

These genes work together in:

  • Converting homocysteine to methionine
  • Supporting cellular methylation
  • Maintaining DNA integrity [13]

6. BHMT (Betaine-Homocysteine Methyltransferase)

BHMT is essential for:

  • Liver function
  • Detoxification
  • Homocysteine regulation is essential for maintaining healthy DNA methylation patterns.
  • Cellular repair [14]

7. MAO A (Monoamine Oxidase Type A)

This gene influences:

  • Neurotransmitter breakdown
  • Mood regulation
  • Sleep patterns
  • Behavioral traits can be influenced by genetic factors associated with methylation. [15]

8. AHCY (Adenosylhomocysteinase)

AHCY affects:

  • Methylation efficiency [16]
  • Cardiovascular health
  • Cellular energy
  • Mental clarity

9. SHMT (Serine Hydroxymethyltransferase)

SHMT is important for:

  • DNA synthesis
  • Red blood cell formation
  • Amino acid metabolism [17]
  • Cellular reproduction

10. SUOX (Sulfite Oxidase)

SUOX is involved with the regulation of methyl groups in metabolic pathways like:

  • Sulfite processing
  • Neural function [18]
  • Cognitive clarity
  • Detoxification support

Benefits of DNA Methylation Testing

Personalized Health Insights

Studies have shown that understanding the unique genetic methylation profile of the individual can help with:

  • Targeted supplementation strategies
  • Customized dietary recommendations
  • Specific lifestyle modifications [19]

Preventive Healthcare

Research indicates that identifying genetic variations early helps with:

  • Proactive health management
  • Risk mitigation strategies
  • Targeted interventions [20]

Clinical Research Support

The importance of methylation testing and support is backed by many clinical studies:

  • A 2023 meta-analysis in the Journal of Clinical Medicine showed significant associations between methylation patterns and health outcomes [21]
  • Research published in Nature Reviews Molecular Cell Biology demonstrated the critical role of methylation in gene expression [22]
  • Studies in Epigenetics have linked methylation patterns to various health conditions [23]

Genetic Methylation Test Results Sample

Genetic Methylation Test Results

References

1. Smith, Z., Meissner, A. DNA methylation: roles in mammalian development. Nat Rev Genet 14, 204–220 (2013).2. Epigenetics, Health, and Disease. CDC.

3. Lister R and Mukamel EA (2015) Turning over DNA methylation in the mind. Front. Neurosci. 9:252. doi: 10.3389/fnins.2015.00252

4. Zhang Y, Zeng C. Role of DNA methylation in cardiovascular diseases. Clin Exp Hypertens. 2016;38(3):261-7. doi: 10.3109/10641963.2015.1107087. Epub 2016 Mar 30. PMID: 27028400.

5. Ruiz-Hernandez, A., Kuo, CC., Rentero-Garrido, P. et al. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Clin Epigenet 7, 55 (2015).

6. Betto, R.M., Diamante, L., Perrera, V. et al. Metabolic control of DNA methylation in naive pluripotent cells. Nat Genet 53, 215–229 (2021).

7. West, A., Shadel, G. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol 17, 363–375 (2017).

8. MTHFR methylenetetrahydrofolate reductase [ Homo sapiens (human) ]

9. Khan A, Waheed A, Afsar T, Abusharha A, Shafique H, Razak S. Unraveling Catechol-O-Methyltransferase rs4680 SNP's Role in Patients' Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management. J Clin Med. 2023 Dec 31;13(1):249.

10. Haussler MR, Haussler CA, Bartik L, Whitfield GK, Hsieh JC, Slater S, Jurutka PW. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr Rev. 2008 Oct;66(10 Suppl 2):S98-112.

11. Uitterlinden AG, Fang Y, van Meurs JB, van Leeuwen H, Pols HA. Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):187-93.

12. Rao G, Murphy B, Dey A, Dwivedi SKD, Zhang Y, Roy RV, Chakraborty P, Bhattacharya R, Mukherjee P. Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells. FASEB J. 2020 Jul;34(7):9372-9392.

13. Ding W, Zhou DL, Jiang X, Lu LS. Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies. PLoS One. 2013 Apr 9;8(4):e60508.

14. Han HK, Mukherjee S, Park SY, Lee JH, Lee EH, Kim S, Lee YH, Song DK, Lee S, Bae JH, Im SS. Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle. Mol Cell Biol. 2024;44(6):245-258.

15. MAOA monoamine oxidase A [ Homo sapiens (human) ]

16. AHCY adenosylhomocysteinase [ Homo sapiens (human) ]

17. HMT1 serine hydroxymethyltransferase 1 [ Homo sapiens (human) ]

18. SUOX sulfite oxidase [ Homo sapiens (human) ]

19. Laplace B, Calvet B, Lacroix A, Mouchabac S, Picard N, Girard M, Charles E. Acceptability of Pharmacogenetic Testing among French Psychiatrists, a National Survey. Journal of Personalized Medicine. 2021; 11(6):446.

20. Heyn, H., Esteller, M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet 13, 679–692 (2012).

21. Zhang YL, Wang YW, He MJ, Chang JL. An updated meta-analysis investigating the association between DNMTs gene polymorphism and gastric cancer risk. PLoS One. 2023 Oct 25;18(10):e0293466.

22. Greenberg, M.V.C., Bourc’his, D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol 20, 590–607 (2019).

23. Smith, Z.D., Hetzel, S. & Meissner, A. DNA methylation in mammalian development and disease. Nat Rev Genet (2024).

Frequently asked questions

Can Genetic Methylation Test be ordered without a doctor?

Genetic Methylation Test can be ordered without a doctor through the "More Details" link.
629

How much does Genetic Methylation Test cost?

Genetic Methylation Test costs
629

What does Genetic Methylation Test test for?

Genetic Methylation Test tests for:
  • Genetic Methylation Test
  • MTHFR (Methylenetetrahydrofolate Reductase)

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